منابع مشابه
Bacterial Exotoxins and the Inflammasome
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. In certain myeloid cells, this activation can also lead to an inflammatory cell death (pyroptosis). Inflammasome sensor proteins have ...
متن کاملBacterial endotoxins.
Endotoxins possess an intrinsic fascination that is nothing less than fabulous. They seem to have been endowed by nature with virtues and vices in the exact and glamorous proportions needed to render them irresistible to any investigator who comes to know them.
متن کاملBacterial pyrogenic exotoxins as superantigens.
The recent discovery of the mode of interaction between a group of microbial proteins known as superantigens and the immune system has opened a wide area of investigation into the possible role of these molecules in human diseases. Superantigens produced by certain viruses and bacteria, including Mycoplasma species, are either secreted or membrane-bound proteins. A unique feature of these prote...
متن کاملHybrid Formation between Bacterial Endotoxins
When endotoxins extracted from enteric bacteria were mixed in the presence of sodium deoxycholate, and the bile salt was subsequently removed by dialysis or by extraction with ethanol, a new type of endotoxin was formed. The latter material was as biologically active as the original endotoxins and possessed a combination of antigenic determinants that were previously unique to each of the indiv...
متن کاملCytidylyl cyclase activity of bacterial exotoxins
3',5'-Cyclic adenosine monophosphate (cAMP) and 3',5'cyclic guanosine monophosphate (cGMP) are key second messengers for a wide variety of mammalian cellular processes. The natural occurrence of a third cyclic nucleotide, 3',5'-cyclic cytidine monophosphate (cCMP) had been discussed very controversially 30–35 years ago [1-3], but later, cCMP was identified unambiguously in various mammalian tis...
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ژورنال
عنوان ژورنال: Kobunshi
سال: 1967
ISSN: 0454-1138,2185-9825
DOI: 10.1295/kobunshi.16.11_1227